CRE Surveillance Case Definition and Reporting

Starting January 1, 2016 Carbapenem-resistant Enterobacteriaceae (CRE) will be reportable statewide under the Communicable Disease Rules, Chapter 4605. CRE reporting is slightly different for residents of Hennepin and Ramsey Counties.

On this page:
What to report statewide
Isolate submission and laboratory testing
Reporting rule change: proposal and notification letters

What to report statewide

• Enterobacteriaceae isolated from any body site, that meet the following criteria:
  • Resistant to imipenem, meropenem, doripenem or ertapenem based on current Clinical and Laboratory Standards Institutes Standards (CLSI) M100 standards; and/or
  • That demonstrate production of a carbapenemase by a recognized method (e.g. Modified Hodge Test or PCR).
• All laboratories are strongly encouraged to report and submit isolates of other Enterobacteriaeae species if resistant to any carbapenem antibiotic.
• Current CLSI minimum inhibitory concentration (MIC) interpretive criteria for carbapenem-resistant Enterobacteriaeae (CRE):

References

• Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing; Twenty-Fourth Informational Supplement (January 2014). CLSI document M100-S24. Wayne, Pennsylvania, 2014.

Isolate submission and laboratory testing

• CRE Isolate Submission and Laboratory Testing
  Information about submitting isolates to MDH PHL.

Reporting rule change: proposal and notification letters

• Proposal for Conducting Statewide Surveillance for Carbapenem-resistant Enterobacteriaceae (CRE) in Minnesota under the Minnesota Communicable Disease Rule (4605.7080) (PDF)
  The proposal explaining the rationale for this change. The commissioner of health has the authority to make this change to the reporting rules per Minn. Rules 4605.7080.
• Commissioner’s letter to Minnesota laboratories regarding CRE surveillance, January 8, 2016 (PDF)
• Commissioner’s letter to Minnesota infection preventionists regarding CRE surveillance, January 8, 2016 (PDF)