CRE Surveillance Case Definition and Reporting - Minnesota Dept. of Health

CRE Surveillance Case Definition and Reporting

Starting January 1, 2016 Carbapenem-resistant Enterobacteriaceae (CRE) will be reportable statewide under the Communicable Disease Rules, Chapter 4605. CRE reporting is slightly different for residents of Hennepin and Ramsey Counties.

On this page:
What to report statewide
Isolate submission and laboratory testing
Reporting rule change: proposal and notification letters

What to report statewide

  • Enterobacteriaceae of the following species Klebsiella spp., Enterobacter spp., E.coli, or Citrobacter spp., isolated from any body site, that meet the following criteria:
    • Resistant to imipenem, meropenem, doripenem or ertapenem based on current Clinical and Laboratory Standards Institutes Standards (CLSI) M100 standards; and/or
    • That demonstrate production of a carbapenemase by a recognized method (e.g. Modified Hodge Test or PCR).
  • All laboratories are strongly encouraged to report and submit isolates of other Enterobacteriaeae species if resistant to any carbapenem antibiotic.
  • Current CLSI minimum inhibitory concentration (MIC) interpretive criteria for carbapenem-resistant Enterobacteriaeae (CRE):
Antibiotic MIC (µg/mL)
Imipenem ≥ 4
Meropenem ≥ 4
Doripenem ≥ 4
Ertapenem ≥ 2

References

  • Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing; Twenty-Fourth Informational Supplement (January 2014). CLSI document M100-S24. Wayne, Pennsylvania, 2014.

Isolate submission and laboratory testing

Reporting rule change: proposal and notification letters

Updated Tuesday, 29-Jan-2019 16:44:50 CST